Novel eukaryotic enzymes modifying cell-surface biopolymers

The fukutin protein family – predicted enzymes modifying cell-surface molecules

Fukuyama type congenital muscular dystrophy (FCMD) is an autosomal recessive disorder that is observed predominantly in Japanese populations [1]. Recently, the cause of this syndrome was discovered to be lesions in the gene encoding the protein fukutin; these lesions involve retroposon insertion and point mutations, which result in a truncated protein [2]. Consistent with the phenotypic pattern...

Detection of Novel Flavonoid-Modifying Enzymes

Corresponding author: 9 Wolfgang R. Streit, Abteilung für Mikrobiologie und Biotechnologie, 10 Biozentrum Klein Flottbek, Universität Hamburg, 11 Ohnhorststraße 18, D-22609 Hamburg, Germany, 12 Telephone: (49) 428 16 463 13 Electronic mail: [email protected] 14 Copyright © 2013, American Society for Microbiology. All Rights Reserved. Appl. Environ. Microbiol. doi:10.1128/AEM.01077-...

SnapShot: Histone-Modifying Enzymes

Eukaryotic stand-alone pseudouridine synthases – RNA modifying enzymes and emerging regulators of gene expression?

For a long time, eukaryotic stand-alone pseudouridine synthases (Pus enzymes) were neglected as non-essential enzymes adding seemingly simple modifications to tRNAs and small nuclear RNAs. Most studies were limited to the identification and initial characterization of the yeast Pus enzymes. However, recent transcriptome-wide mapping of pseudouridines in yeast and humans revealed pervasive modif...

New Nomenclature for Chromatin-Modifying Enzymes

In the last ten years, the importance of chromatin modifications in many aspects of biology has become apparent. Several families of enzymes that modify histones have been identified, the majority of which are conserved throughout evolution. The enormous interest in this field has resulted in a very rapid rate of discovery of new enzymes, but this in turn has lead to a noncoherent nomenclature ...